ResearchWho Lab

#52. Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulation

Myung Sup Kim ; Jung-Hwan Baek ; JinAh Lee ; Aneesh Sivaraman ; Kyeong Lee ; Kyung-Hee Chun

2023.11 · CELL DEATH & DISEASE

(DOI) 10.1038/s41419-023-06317-7

#51. Roles of Protein Post-Translational Modifications During Adipocyte Senescence

Min-Seon Hwang ; Jingyeong Park ; Yunha Ham ; In Hye Lee ; Kyung-Hee Chun

2023.10 · INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES

(DOI) 10.7150/ijbs.86404

#50. Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Jung-Hwan Baek; Myung Sup Kim; Hye Ryeon Jung; Min-Seon Hwang; Chan-Ho Lee; Dai Hoon Han; Yong-Ho Lee; Eugene C Yi; Seung-Soon Im; Ilseon Hwang; Kyungeun Kim; Joon-Yong Chung; Kyung-Hee Chun

2023.07 · EXPERIMENTAL AND MOLECULAR MEDICINE

(ISSN) 1226-3613

#49. Tschimganidine reduces lipid accumulation through AMPK activation and alleviates high-fat diet-induced metabolic diseases

Min-Seon Hwang ; Jung-Hwan Baek ; Jun-Kyu Song ; In Hye Lee ; Kyung-Hee Chun

2023.04 · BMB REPORTS

(ISSN) 1976-6696

#48. Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer

Yesol Kim; Je Yeong Ko; Soo-Been Lee; Sumin Oh; JeeWon Park; Hyeok-Gu Kang; Da-Hyun Kim; Daeun Chung; Sera Lim; Hyunkyung Kong; Jongmin Kim; KyungHyun Yoo; Wonshik Han; Kyung-Hee Chun; Jong Hoon Park

2022.05 · ONCOGENE

(ISSN) 0950-9232

#47. Extracellular Superoxide Dismutase Prevents Skin Aging by Promoting Collagen Production through the Activation of AMPK and Nrf2/HO-1 Cascades

Min Jung Lee ; Gaurav Agrahari ; Hae-Young Kim ; Eun-Joo An ; Kyung-Hee Chun ; Hyeokgu Kang ; Yeon-Soo Kim ; Chul Whan Bang ; Lee-Jung Tak ; Tae-Yoon Kim

2021.10 · JOURNAL OF INVESTIGATIVE DERMATOLOGY

(ISSN) 0022-202X

#46. Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression

Seok-Jun Kim ; Hyeok-Gu Kang ; Kyungeun Kim ; Hoyoung Kim ; Fredrik Zetterberg ; Young Soo Park ; Hyun-Soo Cho ; Stephen M Hewitt ; Joon-Yong Chung ; Ulf J Nilsson ; Hakon Leffler ; Kyung-Hee Chun

2021.09 · GASTRIC CANCER

(ISSN) 1436-3291

#45. Galectin-1 accelerates high-fat diet-induced obesity by activation of peroxisome proliferator-activated receptor gamma (PPARγ) in mice

Jung-Hwan Baek ; Da-Hyun Kim ; Jaegyeong Lee ; Seok-Jun Kim ; Kyung-Hee Chun

2021.01 · CELL DEATH & DISEASE

(DOI) 10.1038/s41419-020-03367-z

#44. Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc

Dong Hoon Lee ; Go Woon Kim ; Jung Yoo ; Sang Wu Lee ; Yu Hyun Jeon ; So Yeon Kim ; Hyeok Gu Kang ; Da-Hyun Kim ; Kyung-Hee Chun ; Junjeong Choi ; So Hee Kwon

2021.01 · CELL DEATH & DISEASE

(DOI) 10.1038/s41419-020-03380-2

#43. Upregulation of LAMB1 via ERK/c-Jun Axis Promotes Gastric Cancer Growth and Motility

Hana Lee ; Won-Jin Kim ; Hyeon-Gu Kang ; Jun-Ho Jang ; Il Ju Choi ; Kyung-Hee Chun ; Seok-Jun Kim

2021.01 · INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

(ISSN) 1661-6596

#42. Synergistic antitumor activity of a DLL4/VEGF bispecific therapeutic antibody in combination with irinotecan in gastric cancer

Da-Hyun Kim ; Seul Lee ; Hyeok Gu Kang ; Hyun-Woo Park ; Han-Woong Lee ; Dongin Kim ; Dong-Hoon Yoem ; Jin-Hyung Ahn ; Eunsin Ha ; Weon-Kyoo You ; Sang Hoon Lee ; Seok-Jun Kim ; Kyung-Hee Chun

2020.11 · BMB REPORTS

(ISSN) 1976-6696

#41. Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer

Sera Lim ; Yesol Kim ; Soo-Been Lee ; Hyeok-Gu Kang ; Da-Hyun Kim ; Jee Won Park ; Daeun Chung ; Hyunkyung Kong ; Kyung Hyun Yoo ; Yonghwan Kim ; Wonshik Han ; Kyung-Hee Chun ; Jong Hoon Park

2020.10 · ONCOGENESIS

(DOI) 10.1038/s41389-020-00275-x

#40. Classifying the Linkage between Adipose Tissue Inflammation and Tumor Growth through Cancer-Associated Adipocytes

Yae Chan Song ; Seung Eon Lee ; Young Jin ; Hyun Woo Park ; Kyung-Hee Chun ; Han-Woong Lee

2020.09 · MOLECULES AND CELLS

(ISSN) 1016-8478

#39. HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53

Sang Ah Yi ; Dong Hoon Lee ; Go Woon Kim ; Hyun-Wook Ryu ; Jong Woo Park ... Hyeok Gu Kang ; Da-Hyun Kim ; Kyung-Hee Chun ; Jueng Soo You ; Jeung-Whan Han ; So Hee Kwon

2020.09 · CELL DEATH AND DIFFERENTIATION

(ISSN) 1350-9047

#38. Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner

Da-Hyun Kim ; Hyun-Woo Lee ; Hyun-Woo Park ; Han-Woong Lee ; Kyung-Hee Chun

2020.08 · BMB REPORTS

(ISSN) 1976-6696

#37. SPON2 Is Upregulated through Notch Signaling Pathway and Promotes Tumor Progression in Gastric Cancer

Hyeon-Gu Kang ; Won-Jin Kim ; Myung-Giun Noh ; Kyung-Hee Chun ; Seok-Jun Kim

2020.06 · CANCERS

(DOI) 10.3390/cancers12061439

#36. Non-classical Role of Galectin-3 in Cancer Progression: Translocation to Nucleus by Carbohydrate-Recognition Independent Manner

Seok-Jun Kim ; Kyung-Hee Chun

2020.04 · BMB REPORTS

(ISSN) 1976-6696

#35. Galectin-3 Interacts With C/EBPβ and Upregulates Hyaluronan-Mediated Motility Receptor Expression in Gastric Cancer

Hyeon-Gu Kang ; Won-Jin Kim ; Hyeok-Gu Kang ; Kyung-Hee Chun ; Seok-Jun Kim

2020.03 · MOLECULAR CANCER RESEARCH

(ISSN) 1541-7786

#34. miR-374a-5p promotes tumor progression by targeting ARRB1 in triple negative breast cancer

Dasom Son ; Yesol Kim ; Sera Lim ; Hyeok-Gu Kang ; Da-Hyun Kim ; Jee Won Park ; Woosung Cheong ; Hyun Kyung Kong ; Wonshik Han ; Woong-Yang Park ; Kyung-Hee Chun ; Jong Hoon Park

2019.07 · CANCER LETTERS

(DOI) 10.1016/j.canlet.2019.04.006

#33. A PDE1 inhibitor reduces adipogenesis in mice via regulation of lipolysis and adipogenic cell signaling

Nam-Jun Kim ; Jung-Hwan Baek ; JinAh Lee ; HyeNa Kim ; Jun-Kyu Song ; Kyung-Hee Chun

2019.01 · EXPERIMENTAL AND MOLECULAR MEDICINE

(DOI) 10.1038/s12276-018-0198-7

#32. The role of hepatic macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Ji-Young Cha ; Da-Hyun Kim ; Kyung-Hee Chun

2018.12 · Laboratory Animal Research

(DOI) 10.5625/lar.2018.34.4.133

#31. Heat Shock Factor 1 Predicts Poor Prognosis of Gastric Cancer

Seok-Jun Kim ; Seok-Cheol Lee ; Hyun-Gu Kang ; Jungsoo Gim ; Kyung-Hwa Lee ; Seung-Hyun Lee ; Kyung-Hee Chun

2018.11 · Yonsei Medical Journal

(DOI) 10.3349/ymj.2018.59.9.1041

#30. Post-translational modification of OCT4 in breast cancer tumorigenesis

Yunhee Cho ; Hyeok Gu Kang ; Seok-Jun Kim ; Seul Lee ; Sujin Jee ; Sung Gwe Ahn ; Min Jueng Kang ; Joon Seon Song ; Joon-Yong Chung ; Eugene C. Yi ; Kyung-Hee Chun

2018.03 · CELL DEATH AND DIFFERENTIATION

(DOI) 10.1038/s41418-018-0079-6

#29. Hexokinase 2 is a molecular bridge linking telomerase and autophagy

Jae-il Roh ; Yujin Kim ; Jahyun Oh ; Yunmi Kim ; Jeehyun Lee ; Jaehoon Lee ; Kyung-Hee Chun ; Han-Woong Lee

2018.02 · PLOS ONE

(DOI) 10.1371/journal.pone.0193182

#28. Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK)

Jung-Hwan Baek ; Nam-Jun Kim ; Jun-Kyu Song ; Kyung-Hee Chun

2017.11 · BMB REPORTS

(DOI) 10.5483/BMBRep.2017.50.11.031

#27. Inter-alpha Inhibitor H4 as a Potential Biomarker Predicting the Treatment Outcomes in Patients with Hepatocellular Carcinoma

Eun-Jung Lee ; Seung-Hyun Yang ; Kyoung-Jin Kim ; Hyejung Cha ; Seo Jin Lee ; Ji-Hye Kim ; Junkyu Song ; Kyung-Hee Chun ; Jinsil Seong

2017.06 · CANCER RESEARCH AND TREATMENT

(DOI) 10.4143/crt.2016.550

#26. Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain

Hyeok Gu Kang ; Da-Hyun kim ; Seok-Jun Kim ; Yunhee Cho ; , Junghyun Jung ; Wonhee Jang ; Kyung-Hee Chun

2016.09 · ONCOTARGET

(DOI) 10.18632/oncotarget.11920

#25. Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism

Sun-Hyuk La ; Seok-Jun Kim ; Hyeok-Gu Kang ; Han-Woong Lee ; Kyung-Hee Chun

2016.08 · ONCOTARGET

(DOI) 10.18632/oncotarget.10986

#24. Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma

Hyun Kyung Kong;Sae Jeong Park;Ye Sol Kim;Kyoung Min Kim; Hyun-Woo Lee; Hyeok-Gu Kang; Yu Mi Woo; Eun Young Park; Je Yeong Ko; Hiromu Suzuki; Kyung-Hee Chun; Erwei Song; Kyu Yun Jang; Jong Hoon Park

2016.08 · ONCOTARGET

(DOI) 10.18632/oncotarget.10972

#23. Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1

2016.08 · CANCER RESEARCH

(DOI) 10.1158/0008-5472.CAN-15-3310

#22. Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway

Ae Lee Jeong ; Sora Han ; Sunyi Lee ; Jeong Su Park ; Yiling Lu ; Shuangxing Yu ; Jane Li ; Kyung-Hee Chun ; Gordon B. Mills ; Young Yang

2016.06 · Scientific Reports

(DOI) 10.1038/srep27391

#21. Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer

Hye-Young Kim ; Yunhee Cho ; HyeokGu Kang ; Ye-Seal Yim ; Seok-Jun Kim ; Jaewhan Song ; Kyung-Hee Chun

2016.06 · ONCOTARGET

(DOI) 10.18632/oncotarget.10231

#20. The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway

Maria Lee ; Hee Jung Kim ; Sang Wun Kim ; Sun-Ae Park ; Kyung-Hee Chun ; Nam Hoon Cho ; Yong Sang Song ; Young Tae Kim

2016.06 · ONCOTARGET

(DOI) 10.18632/oncotarget.10065

#19. A novel miR-34a target, protein kinase D1, stimulates cancer stemness and drug resistance through GSK3/β-catenin signaling in breast cancer

Do Yeon Kim ; Eun Young Park ; EunSun Chang ; Hyeok-Gu Kang ; Yoonjin Koo ; Eun Ji Lee ; Je Yeong Ko ; Hyun Kyung Kong ; Kyung-Hee Chun ; Jong Hoon Park

2016.02 · ONCOTARGET

(DOI) 10.18632/oncotarget.7443

#18. PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

Min-Sik Lee ; Man-Hyung Jeong ; Hyun-Woo Lee ; Hyun-Ji Han ; Aram Ko ; Stephen M. Hewitt ; Jae-Hoon Kim ; Kyung-Hee Chun ; Joon-Yong Chung ; Cheolju Lee ; Hanbyoul Cho ; Jaewhan Song

2015.07 · Nature Communications

(DOI) 10.1038/ncomms8769

#17. Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer

Hyun-Woo Lee ; Seok-Jun Kim ; Il Ju Choi ; Jaewhan Song ; Kyung-Hee Chun

2015.07 · CLINICAL & EXPERIMENTAL METASTASIS

(DOI) 10.1007/s10585-015-9730-5

#16. Cleaved CD44 intracellular domain supports activation of stemness factors and promotes tumorigenesis of breast cancer.

Yunhee Cho ; Hyun-Woo Lee ; Hyeok-Gu Kang ; Hye-Young Kim ; Seok-Jun Kim ; Kyung-Hee Chun

2015.04 · ONCOTARGET

(DOI) 10.18632/oncotarget.3325

#15. Glucose deprivation triggers protein kinase C-dependent β-catenin proteasomal degradation

Seung-Won Choi ; Jun-Kyu Song ; Ye-Seal Yim ; Ho-Geun Yun ; Kyung-Hee Chun

2015.04 · JOURNAL OF BIOLOGICAL CHEMISTRY

(DOI) 10.1074/jbc.M114.606756

#14. Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer

S-J Kim ; H-W Lee ; J-H Baek ; Y-H Cho ; HG Kang ; JS Jeong ; J Song ; H-S Park ; K-H Chun

2015.03 · ONCOGENE

(DOI) 10.1038/onc.2015.80

#13. Galectin-3 activates PPARγ and supports white adipose tissue formation and high-fat diet-induced obesity

Jung-Hwan Baek ; Seok-Jun Kim ; Hyeok Gu Kang ; Hyun-Woo Lee ; Jung-Hoon Kim ; Kyung-A Hwang ; Jaewhan Song ; Kyung-Hee Chun

2015.01 · ENDOCRINOLOGY

(DOI) 10.1210/en.2014-1374

#12. Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy.

Hyun Woo Lee ; Kenny Seung Bin Jang ; Hye Ji Choi ; Ara Jo ; Jae Ho Cheong ; Kyung Hee Chun

2014.12 · BMB REPORTS

(DOI) 10.5483/BMBRep.2014.47.12.069

#11. Targeting of miR34a-NOTCH1 axis reduced breast cancer stemness and chemoresistance

Eun Young Park ; Eun Sun Chang ; Eun Ji Lee ; Hyun Woo Lee ; Hyeok Gu Kang ; Kyung Hee Chun ; Yu Mi Woo ; Hyun Kyung Kong ; Je Yeong Ko ; Hiromu Suzuki ; Erwei Song ; Jong Hoon Park

2014.12 · CANCER RESEARCH

(DOI) 10.1158/0008-5472.CAN-14-1140

#10. Ablation of galectin-3 induces p27KIP1-dependent premature senescence without oncogenic stress.

S-J Kim ; H-W Lee ; H Gu Kang ; S-H La ; Il Ju Choi ; J Y Ro ; R S Bresalier ; J Song ; K-H Chun

2014.06 · CELL DEATH AND DIFFERENTIATION

(DOI) 10.1038/cdd.2014.88

#9. Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer

Seok-Jun Kim ; Yuan-Guo Wang ; Hyun-Woo Lee ; Hyeok Gu Kang ; Sun-Hyuk La ; Il Ju Choi ; Tatsuro Irimura ; Jae Y. Ro ; Robert S. Bresalier ; Kyung-Hee Chun

2014.05 · ONCOTARGET

(DOI) 10.18632/oncotarget.1960

#8. The role of S100A14 in epithelial ovarian tumors

Hanbyoul Cho ; Ha-Yeon Shin ; Sunghoon Kim ; Jane Seon-Young Kim ; Joon-Yong Chung ; Eun Joo Chung ; Kyung-Hee Chun ; Stephen M. Hewitt ; Jae-Hoon Kim

2014.04 · ONCOTARGET

10.18632/oncotarget.1947

#7. Galectin-7 is epigenetically-regulated tumor suppressor in gastric cancer

Seok-Jun Kim ; Jung-Ah Hwang ; Jae Y. Ro ; Yeon-Su Lee ; Kyung-Hee Chun

2013.08 · ONCOTARGET

(DOI) 10.18632/oncotarget.1219

#6. CK2-NCoR signaling cascade promotes prostate tumorigenesis

Jung-Yoon Yoo ; Beom Jin Lim ; Hyo-Kyoung Choi ; Soon Won Hong ; Ho Sung Jang ; Changsoo Kim ; Kyung-Hee Chun ; Kyung-Chul Choi ; Ho-Geun Yoon

2013.05 · ONCOTARGET

10.18632/oncotarget.1020

#5. Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF

Aram Ko ; Ji-Young Shin ; Jinho Seo ; Kang-Duck Lee ; Eun-Woo Lee ; Min-Sik Lee ; Han-Woong Lee ; Il-Ju Choi ; Jin Sook Jeong ; Kyung-Hee Chun ; Jaewhan Song

2012.11 · JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

(ISSN) 0027-8874

#4. STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy.

Ye-Hyeon Ahn ; Hwajung Yi ; Ji-Young Shin ; Kang-Duck Lee ; Seung-Pil Shin ; Sang-Jin Lee ; Jaewhan Song ; Kyung-Hee Chun

2012.04 · CLINICAL & EXPERIMENTAL METASTASIS

(ISSN) 0262-0898

#3. MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7.

Seok-Jun Kim ; Ji-Young Shin ; Kang-Duck Lee ; Young-Ki Bae ; Ki Woong Sung ; Seok Jin Nam ; Kyung-Hee Chun

2012.01 · BREAST CANCER RESEARCH

(DOI) 10.1186/bcr3098

#2. Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis

Eun-Woo Lee ; Jung-Hoon Kim; Ye-Hyeon Ahn ; Jinho Seo ; Aram Ko ; Manhyung Jeong ; Seok-Jun Kim; Jae Y. Ro ; Ki-Moon Park ; Han-Woong Lee ; Eun Jung Park ; Kyung-Hee Chun ; Jaewhan Song

12.07 · Nature Communications

(DOI) 10.1038/ncomms1981

#1. Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression.

Yuan-Guo Wang ; Seok-Jun Kim ; Jung-Hwan Baek ; Hyun-Woo Lee ; Seo-Young Jeong ; Kyung-Hee Chun

12.06 · EXPERIMENTAL AND MOLECULAR MEDICINE

(ISSN) 1226-3613